▎ 摘　　要

A graphene-based electrochemical sensing platform for sensitive determination of baicalein was constructed by means of pulsed potentiostatic reduction of graphene oxide (GO) on a glassy carbon electrode (GCE). The resulting electrode (ERGO/GCE) was characterized by cyclic voltammetry (CV) and scanning electron microscopy (SEM). The electrochemical behaviors of baicalein at the ERGO/GCE were investigated in detail by CV, chronoamperometry (CA) and chronocoulometry (CC). The experimental results demonstrated that the ERGO/GCE exhibited excellent response toward the redox of baicalein as evidenced by the significant enhancement of redox peak currents (i(p)) and the decreased peak-to-peak separation (Delta E-p) in comparison with a bare GCE. Under the optimum experimental conditions, the reduction peak cureent was proportioanal to the baicalein concentration in the range of 5.0 x 10(-9) similar to 5.0 x 10(-7) mol L-1 with the detection limit of 2.0 x 10(-9) mol L-1. The proposed method was also applied successfully to determine baicalein in spiked human blood serum samples.