▎ 摘　　要

A simple and sensitive method for the determination of propranolol using graphene and conductive polymer (poly-1,5-diaminonaphthalene) modified edge plane pyrolytic graphite (EPPG) sensor is presented. The electrochemical measurements and surface morphology of modified sensor was studied using square wave voltammetry, cyclic voltammetry, electrochemical impedance spectroscopy (EIS) and field emission scanning electron microscopy (FE-SEM). The modified sensor exhibited excellent catalytic activity toward electrochemical oxidation of propranolol in phosphate buffer of pH 7.2. The modified sensor facilitated the determination of propranolol in the concentration range 0.1-750 p,M and a detection limit and sensitivity of 20 nM and 0.062 pAhiM were achieved. The proposed method was successfully employed to detect propranolol in pharmaceutical samples, human urine and blood plasma samples. The method showed tremendous reproducibility and intra- and inter-day stability and has proved to be highly reliable for the analysis of propranolol in clinical samples. (C) 2014 Elsevier B.V. All rights reserved.