▎ 摘　　要

Herein, a hybrid nanomaterial of copper-nickel bimetal and reduced graphene (rGO) was simply and quickly synthesized by hydrothermal method, which was characterized by transmission electron microscope, field emission scanning electron microscopy, fourier transform infrared spectroscopy, electrochemical impedance and X-ray diffractometry. A new type of electrochemical sensor was constructed by fixing this hybrid on the glassy carbon electrode (GCE). Square wave voltammetry and cyclic voltammetry indicate that this Cu-Ni/rGO/GCE sensor has highly sensitive electrocatalytic activities to 4-aminophenol (4-AP) and acetaminophen (AC). The linear detection ranges were 0.10 similar to 50.00 mu M for AC and 0.10 similar to 30.00 mu M for 4-AP, with the detection limits of 2.13 nM for AC and 2.19 nM for 4-AP, respectively. The Cu-Ni/rGO/GCE was successfully used for the determination of 4-AP and AC simultaneously of paracetamol tablets, and satisfactory results were obtained.