▎ 摘　　要

In the present work, the surface of graphene oxides (GO) have been modified with biodegradable and hydrophilic polymeric compounds, poly(N-vinylcaprolactam) (PNVCL) and poly(glycolic acid) over covalent functionalization for effectual loading and release of oxaliplatin anticancer drug. The oxaliplatin was loaded onto the graphene oxide surface of GO-PNVCL-PGA composite by the Tc-Tc interactions. The release profile of oxaliplatin from GO-PNVCL-PGA was carried out at two different pHs (5.4 and 7.4) and temperatures (27 and 45 degrees C). The DSC analyze confirmed that the modification of PNVCL with polyglycolide caused to change transition temperatures range from 32 to 34 degrees C to the normal body temperature range (36-37 degrees C). Also, the cytotoxicity effects of oxaliplatin, GO-PNVCL-PGA, and oxaliplatin loaded GO-PNVCL-PGA on human breast cancer cells (MCF-7) was estimated via MTT assay. The outcomes indicated that the cytotoxicity of oxaliplatin loaded GO-PNVCL-PGA was higher than free oxaliplatin. Mainly, oxaliplatin loaded GO-PNVCL-PGA has a more cytotoxic effect than GO-PNVCL-PGA against cancer cells, which was representing that oxaliplatin loaded GO-PNVCL-PGA can be applied as encouraging compound for biological utilization and drug delivery carriers.