▎ 摘　　要

An eco-friendly and sensitive electrode, SnO2-beta-cyclodextrin-graphene oxide modified glassy carbon electrode, was developed for the determination of an antioxidant drug, alpha-lipoic acid (ALA). SnO2 nanoparticles were prepared by the sonication method by the treatment of SnCl2 with extracts of kiwi peel. SnO2-beta-CD-GO was characterized by XRD, FTIR, SEM, UV-Vis and EIS. ALA exhibited enhanced anodic peak current at 0.88V (Epa) in BR buffer of pH 3 with the enhancement of similar to 26-fold at the SnO2-beta-CD-GO/GCE compared to bare electrode. Scan rate studies revealed the electrode process was diffusion controlled. A linearity was observed between the peak current and concentration of ALA in the range of 6.5 x 10(-8)-7.22 x 10(-5) mol L-1 for DPV and 3.12 x 10(-8)-4.99 x 10(-5) mol L-1 for the SWV method. The lower concentration of LOD value of 1.42 x 10(-9) mol L-1 was attained with the SWV method. The proposed sensor demonstrated its applicability for the determination of ALA in pharmaceutical formulations and biological samples.