• 文献标题:   Fabrication and characterization of PCL/Gel nanofibrous scaffolds incorporated with graphene oxide applicable in cardiac tissue engineering
  • 文献类型:   Article
  • 作  者:   FAKHRALI A, POURSHARIFI N, NASARI M, SEMNANI D, SALEHI H, GHANE M, MOHAMMADI S
  • 作者关键词:   human cardiac myocyte, electrospinning, graphene oxide, nanofiber, cardiac tissue engineering
  • 出版物名称:   POLYMERPLASTICS TECHNOLOGY MATERIALS
  • ISSN:   2574-0881 EI 2574-089X
  • 通讯作者地址:  
  • 被引频次:   3
  • DOI:   10.1080/25740881.2021.1939716 EA JUL 2021
  • 出版年:   2021

▎ 摘  要

Herein, we fabricated poly (caprolactone)/Gelatin (PCL/Gel) nanofibrous scaffolds and graphene oxide (GO 0.3, 0.6 and 1% w/w) was incorporated into scaffolds. Morphological, structural, mechanical and in vitro analyses of the samples were performed. The diameter of PCL nanofibers was increased by adding Gel and GO, especially by adding 1%w/w of GO (210 +/- 20 nm versus 482 +/- 104 nm). Mechanical properties and hydrophilicity were improved. All scaffolds were nontoxic and the most biocompatibility values obtained were 91.71 +/- 0.1% and 94.29 +/- 1.1%, which were related to PCL/Gel and PCL/Gel/GO(0.3), respectively. Among all samples, PCL/Gel/GO(0.3) showed the highest cell area (0.973 +/- 0.041).