▎ 摘　　要

Cost-effective nanomaterials are of significant interest in cancer biomarker detection in biomedical research with accuracy. Herein, we have developed a sensitive electrochemical sensor platform with yttrium oxide/graphene oxide (Y2O3/GO) binary sheets (BS) for 3-nitro-L-tyrosine (NTS) cancer biomarker detection in a biological sample. We used the simple, greener, and nontoxic ultrasonication method to synthesize the Y2O3/GO BS. The physicochemical properties of Y2O3/GO BS were analyzed using powder x-ray diffraction (PXRD) and various microscopy and spectroscopy technics. As a result, Y2O3/GO BS-based electrochemical sensor holds excellent electrocatalytic activity towards NTS detection with a wide concentration range (5 nM to 717.205 mu M), a low detection limit (LOD) of 1.1 nM, and a good sensitivity of 0.4605 mu A.mu M- 1.cm- 2. Additionally, the Y2O3/GO BS/ GCE sensor was successfully used to analyze a biological sample and displayed satisfactory outcomes. The present report demonstrates an effective strategy to develop a cheap and sensitive electrochemical sensing platform for biomarker determination.