• 文献标题:   Reduced Graphene Oxide-Based Assay for Real-Time Monitoring of Cancer Cell Viability
  • 文献类型:   Article
  • 作  者:   WU J, TANG Y, SHI ZL, TIAN ZS, WANG JH, YANG C, LI JT, XIAO ZD, XU CX
  • 作者关键词:   reduced graphene oxide, biosensor, colon cancer, real time
  • 出版物名称:   NANO
  • ISSN:   1793-2920 EI 1793-7094
  • 通讯作者地址:   Southeast Univ
  • 被引频次:   0
  • DOI:   10.1142/S1793292015500940
  • 出版年:   2015

▎ 摘  要

Viability of cancer cell is an important indicator of physiological state and function of cells, which can be effected by the change of pH in the medium solution, due to the increase of carbon oxide and lactic acid caused by respiration. Although many methods have been developed to detect the viability of cells, mostly based on cytochemical staining and polymerase chain reaction (PCR) technology are time consuming. In this paper, an electronic device was made by thermal reduced graphene oxide (RGO) for detection of cancer cell viability in real-time. This electronic device could be used to monitor the metabolic activity and viability of cancer cells based on the change in pH value. As the pH decreases, colon cancer cells loose viability and the current decreases. This RGO device is simple, sensitive and label-free and could serve as a platform for detection of cells and drug testing.