• 文献标题:   In vitro bioactivity of baghdadite-coated PCL -graphene nanocomposite scaffolds: mechanism of baghdadite and apatite formation
  • 文献类型:   Article, Early Access
  • 作  者:   AREFPOUR A, KASIRIASGARANI M, MONSHI A, KARBASI S, DOOSTMOHAMMADI A, ROSTAMI S
  • 作者关键词:   apatite, baghdadite, bioactivity, graphene, nanocomposite
  • 出版物名称:   MATERIALS TECHNOLOGY
  • ISSN:   1066-7857 EI 1753-5557
  • 通讯作者地址:   Islamic Azad Univ
  • 被引频次:   0
  • DOI:   10.1080/10667857.2020.1794281 EA JUL 2020
  • 出版年:  

▎ 摘  要

The aim of the present research was to find out the in vitro biological behaviour by evaluating the bioactivity of scaffolds for bone tissue engineering and to examine the mechanism of baghdadite and apatite formation. For this purpose, baghdadite scaffolds with polycaprolactone and graphene nanocomposite coatings were fabricated using polymeric sponge and dipcoating methods. Results showed that regarding baghdadite formation mechanism, gittinsite phase can be converted into baghdadite phase by enhancing temperature up to 1350 degrees C and helping Zr4+ and Ca2+. The deposit of Ca-P coatings on the surface and in the pores of the scaffolds verified the improvement of the bioactivity. Graphene in scaffold composition can affect apatite deposit formation and promise bioactivity due to its high hydrophilicity, existence of nanoparticles and great p bonds in its structure. In brief, baghdadite scaffolds with polycaprolactone and graphene nanocomposite coatings can be promising outstanding candidates for bone tissue engineering. [GRAPHICS]