• 文献标题:   Design of "Turn-Off" Fluorescent Nanoprobe for Highly Sensitive Detection of Uric Acid using Green Synthesized Nitrogen-Doped Graphene Quantum Dots
  • 文献类型:   Article
  • 作  者:   NANGARE S, BAVISKAR S, PATIL A, PATIL P
  • 作者关键词:   graphene quantum dot, ngqd, uric acid, biosensor, tamarind shell powder
  • 出版物名称:   ACTA CHIMICA SLOVENICA
  • ISSN:   1318-0207 EI 1580-3155
  • 通讯作者地址:  
  • 被引频次:   0
  • DOI:   10.17344/acsi.2022.7333
  • 出版年:   2022

▎ 摘  要

Green synthesized graphene quantum dots (GQD) have been doped with nitrogen in an attempt to boost their optical characteristics and application sectors. In the present investigation, the blue luminescent nitrogen-doped GQDs (N-GQDs) were synthesized by single-step hydrothermal synthesis using tamarind shell powder as a precursor. The particle size and zeta potential of N-GQDs were found to be 11.40 nm and be -35.53 mV, respectively. A quantum yield as high as 23.78 % was accomplished at an excitation wavelength of 330 nm at neutral pH. It gets quenched sensitively in the existence of uric acid (UA) combining static quenching, electron transfer, and an inner filter effect mechanism. A linear range was obtained for UA from 10 mu M to 100 mu M, with a limit of detection (LOD) of 401.72 +/- 0.04 pM. Additionally, the N-GQDs were selective toward UA in presence of metal ions and biomolecules that indicated its impending use to monitor UA in clinical samples. In conclusion, this work demonstrates that the N-GQDs as a sensing probe for UA recognition with notable advantages including socioeconomic, simple, and less time-consuming methods as compared to other methods. In the future, it can be potentially explored as a biosensor for UA detection in clinical samples.