• 文献标题:   Graphene microfiber as a scaffold for regulation of neural stem cells differentiation
  • 文献类型:   Article
  • 作  者:   GUO WB, QIU JC, LIU JQ, LIU H
  • 作者关键词:  
  • 出版物名称:   SCIENTIFIC REPORTS
  • ISSN:   2045-2322
  • 通讯作者地址:   Linyi Univ
  • 被引频次:   9
  • DOI:   10.1038/s41598-017-06051-z
  • 出版年:   2017

▎ 摘  要

We report the cytocompatibility and regulating effects of the nanostructured reduced graphene oxide (rGO) microfibers, which are synthesized through a capillary hydrothermal method, on neural differentiation of neural stem cells (NSCs). Our findings indicate that the flexible, mechanically strong, surface nanoporous, biodegradable, and cytocompatible nanostructured rGO microfibers not only offer a more powerful substrate for NSCs adhesion and proliferation compared with 2D graphene film and tissue cluture plate but also regulate the NSCs differentiation into neurons and form a dense neural network surrounding the microfiber. These results illustrate the great potential of nanostructured rGO microfibers as an artificial neural tissue engineering (NTE) scaffold for nerve regeneration.