▎ 摘　　要

The combination of a commercially available PGLA (poly[glycolide-co-l-lactide]), 90:10% suture material with bioactivebioglass nanopowders (BGNs) and graphene oxide (GO)-doped BGNs offersnew opportunities for the clinical application of biomaterials insoft tissue engineering. In the present experimental work, we demonstratethat GO-doped melt-derived BGNs were synthesized via the sol-gelprocess. After that, novel GO-doped and undoped BGNs were used tocoat resorbable PGLA surgical sutures, thereby imparting bioactivity,biocompatibility, and accelerated wound healing properties to thesutures. Stable and homogeneous coatings on the surface of the sutureswere achieved using an optimized vacuum sol deposition method. Thephase composition, morphology, elemental characteristics, and chemicalstructure of uncoated and BGNs- and BGNs/GO-coated suture sampleswere characterized using Fourier transform infrared spectroscopy,field emission scanning electron microscopy, associated with elementalanalysis, and knot performance test. In addition, in vitro bioactivitytests, biochemical tests, and in vivo tests were performed to examinethe role of BGNs and GO on the biological and histopathological propertiesof the coated suture samples. The results indicated that the formationof BGNs and GO was enhanced significantly on the suture surface, whichallowed for enhanced fibroblast attachment, migration, and proliferationand promoted the secretion of the angiogenic growth factor to speedup wound healing. These results confirmed the biocompatibility ofBGNs- and BGNs/GO-coated suture samples and the positive effect ofBGNs on the behavior of L929 fibroblast cells and also showed forthe first time the possibility that cells can adhere and proliferateon the BGNs/GO-coated suture samples, especially in an in vivo environment.Resorbable surgical sutures with bioactive coatings, such as thoseprepared herein, can be an attractive biomaterial not only for hardtissue engineering but also for clinical applications in soft tissueengineering.