▎ 摘　　要

Developing generic strategies for building adaptable; or multifunctional bioplatforms is challenging, in particular because protein immobilization onto surfaces often causes loss of protein function and because multifunctionality usually necessitates specific combinations of heterogeneous elements. Here, we introduce a generic, modular bioplatform construction strategy that uses cage-like supramolecular multienzyme complexes as highly adaptable building blocks immobilized directly and noncovalently on graphene. Thermoplasma acidophilum dihydrolipoyl acyltransferase (E2) supramolecular complexes organize as a monolayer :or can be controllably transferred onto graphene, preserving their supramolecular form with specific molecular recognition capability and capacity for engineering multifunctionality. This E2 graphene platform can-bind enzymes (here, E1, E2's physiological partner) without loss of enzyme function; in this test case, El catalytic activity was detected on E2-graphene over 6 orders of magnitude in substrate concentration. The E2 graphene platform can be multiplexed via patterned: cotransfer of differently modified E2 complexes. As the E2 complexes are robust and highly customizable, E2 graphene is a platform onto which multiple functionalities can be built.