▎ 摘　　要

A GO-Cu(I)Br nanocatalyst has been prepared, and applied for the synthesis of bis(indolyl) methanes. The catalyst is highly effective, is required in much lower amounts (0.05 mol%), and is recyclable for up to six reaction cycles without loss in activity. The synthesized compounds have been screened for their in vitro anti-HIV-1 activity, and compound 3d has shown significant anti-HIV-1 effects. Molecular modelling of 3d with reverse transcriptase enzyme has been carried out to understand its binding mechanism to the active enzyme site.