• 文献标题:   Polyamidoamine dendrimer decorated graphene oxide as a pH-sensitive nanocarrier for the delivery of hydrophobic anticancer drug quercetin: a remedy for breast cancer
  • 文献类型:   Article
  • 作  者:   MATIYANI M, RANA A, PAL M, DOKWAL S, SAHOO NG
  • 作者关键词:   graphene oxide, poly amido amine, drug delivery, quercetin, breast cancer
  • 出版物名称:   JOURNAL OF PHARMACY PHARMACOLOGY
  • ISSN:   0022-3573 EI 2042-7158
  • 通讯作者地址:  
  • 被引频次:   0
  • DOI:   10.1093/jpp/rgad036 EA MAY 2023
  • 出版年:   2023

▎ 摘  要

Objectives The aim of this study was to investigate the potential of poly(amido amine) (PAMAM) dendrimer decorated graphene oxide (GO) based nanocarrier for targeted delivery of a hydrophobic anticancer drug, quercetin (QSR). Methods GO-PAMAM was successfully synthesized by covalent bonding between GO and NH2-terminated PAMAM dendrimer (zero generation). To investigate drug loading performance, QSR was loaded on the surface of GO as well as GO-PAMAM. Further, the release behaviour of QSR-loaded GO-PAMAM was studied. Finally, an in-vitro sulforhodamine B assay was performed in HEK 293T epithelial cells and MDA MB 231 breast cancer cells. Key findings It was observed that GO-PAMAM shows higher QSR loading capacity compared to GO. Also, synthesized nanocarrier exhibits controlled as well as pH-responsive release of QSR and the amount of QSR released at pH 4 was approximately two times higher than the release at pH 7.4. Furthermore, GO-PAMAM was found to be biocompatible for HEK 293T cells, and a high cytotoxic effect was observed for QSR-loaded GO-PAMAM on MDA MB 231 cells. Conclusions The present investigation highlights the potential application of synthesized hybrid materials as a nanocarrier with excellent loading and controlled releasing efficiency for the delivery of the hydrophobic anticancer drug.