▎ 摘　　要

Glucose monitoring is of great significance for the health management of diabetic patients. Herein, non-enzymatic glucose sensors were developed by modifying Au@CuO or Au@CuO/V2CTx MXene nanocomposites (NCs) on the surface of disposable laser-induced graphene (LIG) electrode. The structures and morphologies were confirmed by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and elemental analysis. The electrochemical performances of NCs were investigated by electrochemical impedance spectros-copy (EIS), cyclic voltammetry (CV) and chronoamperometry (CA). The results demonstrated that both Au@CuO/LIG and Au@CuO/V2CTx MXene/LIG have excellent electrocatalytic activity for glucose oxidation in an alkaline medium. However, it was found that Au@CuO/V2CTx MXene/LIG was easily oxidized. Hence, the combination of Au@CuO/LIG was preferred for glucose test. Under optimized conditions, the electrochemical sensor achieved a detection range of 0.005 to 5.0 mM with a sensitivity of 1.124 x 106 mu A mM-1 cm-2. The response time was 1.5 s and the limit of detection (LOD) was as low as 1.8 mu M. The sensor has good selectivity and stability (84.12 % activity retained after 6 weeks). Its affordable price, disposable usage and portable essence are suitable for clinical application. Our study presented a novel strategy to the field of non-enzymatic glucose sensing.