• 文献标题:   MC3T3-E1 preosteoblast cell-mediated mineralization of hydroxyapatite by poly-dopamine-functionalized graphene oxide
  • 文献类型:   Article
  • 作  者:   CHENG J, LIU HY, ZHAO BJ, SHEN R, LIU D, HONG JP, WEI H, XI PX, CHEN FJ, BAI DC
  • 作者关键词:   graphene oxide, polydopamine, biomimetic, mineralization, cell mediated
  • 出版物名称:   JOURNAL OF BIOACTIVE COMPATIBLE POLYMERS
  • ISSN:   0883-9115 EI 1530-8030
  • 通讯作者地址:   Lanzhou Univ
  • 被引频次:   15
  • DOI:   10.1177/0883911515569918
  • 出版年:   2015

▎ 摘  要

We report a biomimetic mineralization of hydroxyapatite induced by poly-dopamine-functionalized reduced graphene oxide (RGO-PDA). Graphene oxide was first simultaneously reduced and surface functionalized by one-step oxidative polymerization of dopamine. The resultant RGO-PDA was further used as a bioinspired surface to mimic the mineralization of hydroxyapatite during bone formation. MC3T3-E1 cells were cultured on the RGO-PDA substrates to observe various cellular activities and hydroxyapatite mineralization. The MC3T3-E1 cells on RGO-PDA substrates show higher cellular activities such as proliferation, adhesion, and osteogenic differentiation over the bare glass and graphene oxide substrates. Those results suggest the potentials of using RGO-PDA as osteogenesis-promoting scaffolds for successful applications in bone tissue regeneration.