• 文献标题:   Modeling of a highly sensitive MoS2-Graphene hybrid based fiber optic SPR biosensor for sensing DNA hybridization
  • 文献类型:   Article
  • 作  者:   RAHMAN MS, ANOWER MS, RAHMAN MK, HASAN MR, HOSSAIN MB, HAGUE MI
  • 作者关键词:   optical fiber biosensor, surface plasmon resonance, resonance angle, dna hybridization, mos2graphene hybrid, sensitivity
  • 出版物名称:   OPTIK
  • ISSN:   0030-4026
  • 通讯作者地址:   Rajshahi Univ Engn Technol
  • 被引频次:   16
  • DOI:   10.1016/j.ijleo.2017.05.001
  • 出版年:   2017

▎ 摘  要

Optical fiber instead of prism is now widely studied in biosensing research. This paper investigates a highly sensitive optical fiber based Ag-MoS2-Graphene hybrid surface plasmon resonance (SPR) biosensor for sensing DNA hybridization. Sensitivity, detection accuracy and quality factor are carefully studied for the performance analysis. Numerical study shows that usingsingle layer of MoS2 in the middle of a Graphene-on-Ag layer, the fiber optic biosensor exhibits high sensitivity of 105.71 degrees/RIU with reasonable detection accuracy and quality factor of 1.626 and 23.23 RIU-1, respectively. This enhanced sensitivity is due to the absorption ability and optical characteristics of graphene biomolecules and high fluorescence quenching ability of MoS2. Numerical investigation also reflects the variation of resonance angle and spectrum of transmitted power for mismatched DNA strands and for complementary DNA strands. These variations are negligible for mismatched DNA strands whereas significantly computable for complementary DNA strands. Thus the proposed sensor effectively differentiates hybridization and single nucleotide polymorphisms (SNP) by examining the level of changes in resonance angle and transmitted power spectrum. Therefore, this fiber optic based Ag-MoS2-Graphene hybrid biosensor might be a promising candidate for the detection of DNA hybridization. (C) 2017 Elsevier GmbH. All rights reserved.