• 文献标题:   3D spongy graphene-modified screen-printed sensors for the voltammetric determination of the narcotic drug codeine
  • 文献类型:   Article
  • 作  者:   MOHAMED MA, ELGENDY DM, AHMED N, BANKS CE, ALLAM NK
  • 作者关键词:   green synthesi, spongy graphene, screenprinted sensor, codeine, adenine
  • 出版物名称:   BIOSENSORS BIOELECTRONICS
  • ISSN:   0956-5663 EI 1873-4235
  • 通讯作者地址:   Natl Org Drug Control Res
  • 被引频次:   19
  • DOI:   10.1016/j.bios.2017.10.020
  • 出版年:   2018

▎ 摘  要

Adenine-functionalized spongy graphene (FSG) composite, fabricated via a facile and green synthetic method, has been explored as a potential electrocatalyst toward the electroanalytical sensing of codeine phosphate (COD). The synthesized composite is characterized using Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, X-ray powder diffraction, UV-vis absorption spectroscopy, scanning electron microscopy, high resolution transmission electron microscopy (HRTEM), and thermogravimetric analysis. The FSG was electrically wired via modification upon screen-printed (macro electrode) sensors, which behave as a hybrid electrode material for the sensitive and selective codeine phosphate (COD) determination in the presence of paracetamol (PAR) and caffeine (CAF). The FSG- modified sensor showed an excellent electrocatalytic response towards the sensing of COD with a wide linear response range of 2.0 x 10(-8)-2.0 x 10(-4) M and a detection limit (LOD) of 5.8 x 10(-9) M, indicating its potential for the sensing of COD in clinical samples and pharmaceutical formulations.