▎ 摘　　要

In this paper, an excellent water-soluble platform derived from a -cyclodextrin derivative and graphene oxide was synthesized and characterized. Moreover, by a supramolecular host-guest self-assembly interaction between the organic molecule and the water-soluble platform, an interesting supramolecular system was fabricated successfully. By fluorescence experiments toward several metal ions, a higher response toward Al3+ than other commonly coexistent metal ions in absolute water media (pH = 7.2) was shown. Meanwhile, a large binding constant (3.89 x 10(12) M-1) between them was calculated by fluorescence titration experiments. In addition, fluorescence imaging in living cells was studied systemically, which exhibited a high fluorescence sensing activity toward Al3+. This study provides the first detailed supramolecular host-guest self-assembled nanosensor from graphene oxide and -cyclodextrin derivatives. Its water-solubility and excellent sensing activity effectively enhanced the application value of the fluorescent nanosensor for tracking and detecting Al3+ in the environment and in organisms.