▎ 摘　　要

A potentiometric sensor modified with a nanocomposite of montmorillonite sheets decorated with polyaniline nanofibers (MT-PANI-NFs) as an efficient electroactive material and tricresyl phosphate (TCP) as a solvent mediator has been developed for the estimation of clomipramine HCl (CLP.HCl). The optimum potentiometric performance of the sensor was achieved by mixing of MT-PANI-NFs : TCP : graphene with a ratio of 2.69 : 30.11 : 67.20 (% wt/wt). The sensor exhibited a Nernstian slope of 59.0 +/- 0.1 mV decade(-1) over the concentration range of 1.0x10(-5)-1.0x10(-2) mol L-1 with a theoretically calculated detection limit of 5.0x10(-6) mol L-1. The sensor performance was scrutinized in terms of several factors including thermal stability, pH effect, response time and selectivity. As, it displayed a high thermal stability at various temperature degrees (10-60 degrees C) with pH independency in the range of 3.5-8.5. Additionally, the developed sensor exhibited a very rapid performance for CLP.HCl detection with a fast response time of 4 s and reflecting a superior selectivity towards CLP.HCl over the other interfering species. SEM (scanning electron microscope) was used as a characteristic tool for the investigation of the proposed graphene sensor surface. Furthermore, the graphene sensor has been efficiently used for CLP.HCl estimation in its pharmaceutical formulations.