• 文献标题:   Preparation and characterization of graphene oxide-Chitosan composite film for ultrathin hyaluronic acid hydrogels
  • 文献类型:   Article
  • 作  者:   TAN SQ, HUANG YS, LAN J, HAN X, CEN RJ, ZHAO XH, LAO YH
  • 作者关键词:   chitosan, graphene oxide, mechanical propertie, porous film, hydrogel skeleton, cytotoxicity
  • 出版物名称:   MATERIALS TECHNOLOGY
  • ISSN:   1066-7857 EI 1753-5557
  • 通讯作者地址:  
  • 被引频次:   2
  • DOI:   10.1080/10667857.2022.2059045 EA APR 2022
  • 出版年:   2022

▎ 摘  要

Mechanical properties of hyaluronic acid (HA) hydrogels are too poor to be prepared as an ultra-thin hydrogels, so to provide a supporting skeleton for them is important. Herein, the porous film based on chitosan(CS)?PEG-20000 and graphene oxide (GO) were prepared for ultra-thin hydrogels. CS is a suitable polymer to prepare films. The added PEG-20000 endowed the film porosity. And the addition of GO improved the mechanical of the film. When CS:PEG = 3:2 and the GO solution proportion was 15%, the porous film exhibited the best comprehensive properties, with a tensile strength of 5.593 MPa, an elongation at break of 45.833%, a water permeation of 1.4099 g at 12 h, a porosity of 62.3% and an average pore size of 1.88 um. Blood compatibility experiments and cell experiments have proved that the film hydrogel has strong biocompatibility, indicating it can be a promising biomaterial.