• 文献标题:   Graphene Oxide Induces Ester Bonds Hydrolysis of Poly-l-lactic Acid Scaffold to Accelerate Degradation
  • 文献类型:   Article
  • 作  者:   SHUAI CJ, LI Y, YANG WJ, YU L, YANG YW, PENG SP, FENG P
  • 作者关键词:   polyllactic acid scaffold, go, degradation property, ester bonds hydrolysi
  • 出版物名称:   INTERNATIONAL JOURNAL OF BIOPRINTING
  • ISSN:   2424-7723 EI 2424-8002
  • 通讯作者地址:   Cent S Univ
  • 被引频次:   5
  • DOI:   10.18063/ijb.v6i1.249
  • 出版年:   2020

▎ 摘  要

Poly-l-lactic acid (PLLA) possesses good biocompatibility and bioabsorbability as scaffold material, while slow degradation rate limits its application in bone tissue engineering. In this study, graphene oxide (GO) was introduced into the PLLA scaffold prepared by selective laser sintering to accelerate degradation. The reason was that GO with a large number of oxygen-containing functional groups attracted water molecules and transported them into scaffold through the interface microchannels formed between lamellar GO and PLLA matrix. More importantly, hydrogen bonding interaction between the functional groups of GO and the ester bonds of PLLA induced the ester bonds to deflect toward the interfaces, making water molecules attack the ester bonds and thereby breaking the molecular chain of PLLA to accelerate degradation. As a result, some micropores appeared on the surface of the PLLA scaffold, and mass loss was increased from 0.81% to 4.22% after immersing for 4 weeks when 0.9% GO was introduced. Besides, the tensile strength and compressive strength of the scaffolds increased by 24.3% and 137.4%, respectively, due to the reinforced effect of GO. In addition, the scaffold also demonstrated good bioactivity and cytocompatibility.