• 文献标题:   pH-sensitive drug delivery based on chitosan wrapped graphene quantum dots with enhanced fluorescent stability
  • 文献类型:   Article
  • 作  者:   SHENG YS, DAI W, GAO J, LI HD, TAN WS, WANG JW, DENG LH, KONG Y
  • 作者关键词:   chitosan, graphene quantum dot, fluorescent stability, drug delivery, cytarabine
  • 出版物名称:   MATERIALS SCIENCE ENGINEERING CMATERIALS FOR BIOLOGICAL APPLICATIONS
  • ISSN:   0928-4931 EI 1873-0191
  • 通讯作者地址:   Changzhou Univ
  • 被引频次:   3
  • DOI:   10.1016/j.msec.2020.110888
  • 出版年:   2020

▎ 摘  要

Graphene quantum dots (GQDs) were prepared by the pyrolysis of citric acid (CA), which were used for the loading of hydrophilic cytarabine (Cyt), an anti-cancer drug, and then wrapped with chitosan (CS) gels for the encapsulation of the loaded Cyt. The fluorescent stability of GQDs was significantly enhanced in the presence of CS, which might be attributed to the inhibited agglomeration of GQDs by the CS gels. In addition, the burst release of Cyt from the developed carrier was also effectively relieved by the CS coating. Since the incorporation of Cyt into GQDs was achieved by amidation reaction, the delivery of Cyt from the carrier was pH-sensitive due to the hydrolysis of the amido linkage between GQDs and Cyt in acidic medium.