• 文献标题:   Apoptotic and anti-apoptotic genes transcripts patterns of graphene in mice
  • 文献类型:   Article
  • 作  者:   AHMADIAN H, HASHEMI E, AKHAVAN O, SHAMSARA M, HASHEMI M, FARMANY A, JOUPARI MD
  • 作者关键词:   graphene, apoptosi, kidney, liver, mouse
  • 出版物名称:   MATERIALS SCIENCE ENGINEERING CMATERIALS FOR BIOLOGICAL APPLICATIONS
  • ISSN:   0928-4931 EI 1873-0191
  • 通讯作者地址:   Natl Inst Genet Engn Biotechnol
  • 被引频次:   3
  • DOI:   10.1016/j.msec.2016.09.073
  • 出版年:   2017

▎ 摘  要

Recent studies showed that a large amount of graphene oxide accumulated in kidney and liver when it injected intravenously. Evaluation of lethal and apoptosis gene expression in these tissues, which are under stress is very important. In this paper the in vivo dose-dependent effects of graphene oxide and reduced graphene oxide nanoplatelets on kidney and liver of mice were studied. Balb/C mice were treated by 20 mg/kg body weight of nanoplatelets. Molecular biology analysis showed that graphene nanoplatelets injected intravenously lead to overexpression of BAX gene in both kidney and liver tissues (P >= 0.01). In addition these nanoparticles significantly increase BCL2 gene expression in both kidney and liver tissues (P >= 0.05). Graphene significantly increase level of SGPT in groups 1 (220.64 +/- 13), 2 (164.44 +/- 9.3) in comparison to control group (P