• 文献标题:   Graphene-based stochastic sensors for pattern recognition of gastric cancer biomarkers in biological fluids
  • 文献类型:   Article
  • 作  者:   STEFANVAN STADEN RI, ILIEMIHAI RM, POGACEAN F, PRUNEANU S
  • 作者关键词:   protoporphyrin ix, stochastic sensor, gastric cancer biomarker
  • 出版物名称:   JOURNAL OF PORPHYRINS PHTHALOCYANINES
  • ISSN:   1088-4246 EI 1099-1409
  • 通讯作者地址:   Natl Inst Res Electrochem Condensed Matter
  • 被引频次:   2
  • DOI:   10.1142/S1088424619501293
  • 出版年:   2019

▎ 摘  要

This paper proposes pattern recognition of gastric cancer biomarkers CEA, CA19-9 and p53 in whole blood and urine samples using a stochastic sensor based on exfoliated graphene (E-NGr) paste modified with protoporphyrin IX. The proposed sensor covered large ranges of concentrations: 1 x 10(-12)-1 x 10(-7) mu g/mL for CEA, 1 x 10(-13)-1 x 10(2) U/mL for CA19-9, and 0.2-5.0 mu g/mL for p53. These ranges allowed the determination of the three biomarkers from early to latest stages of gastric cancer. Validation of the pattern recognition of gastric cancer biomarkers was accomplished using biological samples: whole blood and urine.