• 文献标题:   Adsorption and binding dynamics of graphene-supported phospholipid membranes using the QCM-D technique
  • 文献类型:   Article
  • 作  者:   MELENDREZ D, JOWITT T, ILIUT M, VERRE AF, GOODWIN S, VIJAYARAGHAVAN A
  • 作者关键词:  
  • 出版物名称:   NANOSCALE
  • ISSN:   2040-3364 EI 2040-3372
  • 通讯作者地址:   Univ Manchester
  • 被引频次:   7
  • DOI:   10.1039/c7nr05639g
  • 出版年:   2018

▎ 摘  要

We report on the adsorption dynamics of phospholipid membranes on graphene-coated substrates using the quartz crystal microbalance with dissipation monitoring (QCM-D) technique. We compare the lipid vesicle interaction and membrane formation on gold and silicon dioxide QCM crystal surfaces with their graphene oxide (GO) and reduced (r) GO coated counterparts, and report on the different lipid structures obtained. We establish graphene derivative coatings as support surfaces with tuneable hydrophobicity for the formation of controllable lipid structures. One structure of interest formed is lipid monolayer membranes which were formed on rGO, which are otherwise challenging to produce. We also demonstrate and monitor biotin-avidin binding on such a membrane, which will then serve as a platform for a wide range of biosensing applications. The QCM-D technique could be extended to both fundamental studies and applications of other covalent and non-covalent interactions in 2-dimensional materials.