▎ 摘　　要

The development of novel single-atom catalysts is important for highly efficient electrochemical catalysis and sensing. In this work, a novel Pt single atoms (SAs) supported on Ni6Co1 layered double hydroxides/nitrogen-doped graphene (Pt-1/Ni(6)Co(1)LDHs/NG) was constructed for electrochemical enzyme-free catalysis and sensing towards glucose. The loading of Pt single atoms increases with doping of Co atoms that generate more anchoring sites for Pt SAs. The resulting Pt-1/Ni(6)Co(1)LDHs/NG exhibits low oxidative potential of 0.440 V with high sensitivity of 273.78 mu A.mM(-1).cm(-2) toward glucose, which are 85 mV lower and 15 times higher than those of Ni(OH)(2), respectively. Pt-1/Ni(6)Co(1)LDHs/NG also shows excellent selectivity and great stability during 5-week testing. Theoretical and experimental results show that the boosted performance of Pt-1/Ni(6)Co(1)LDHs/NG originates from its stronger binding energy with glucose and the synergistic effect of Pt SAs, Co doping, and NG. This work provides a general strategy of designing highly active SACs for extending their application in electrochemical sensing.