• 文献标题:   Photoresponsive Protein-Graphene-Protein Hybrid Capsules with Dual Targeted Heat-Triggered Drug Delivery Approach for Enhanced Tumor Therapy
  • 文献类型:   Article
  • 作  者:   HU SH, FANG RH, CHEN YW, LIAO BJ, CHEN IW, CHEN SY
  • 作者关键词:  
  • 出版物名称:   ADVANCED FUNCTIONAL MATERIALS
  • ISSN:   1616-301X EI 1616-3028
  • 通讯作者地址:   Natl Tsing Hua Univ
  • 被引频次:   59
  • DOI:   10.1002/adfm.201400080
  • 出版年:   2014

▎ 摘  要

A novel photo-responsive protein-graphene-protein (PGP) capsule that doubles as a photothermal agent with core/shell structure is constructed by anchoring reduced graphene oxide nanosheets on one-component protein (lactoferrin) shell through a double emulsion method. PGP capsules can transport fully concealed hydrophilic anticancer cargo, doxorubicin (Dox), with a large payload (9.43 mu mol g(-1)) to be later unloaded in a burst-like manner by photo-actuation triggered by near-infrared irradiation. Being bio-compatible yet with a high cancer cell targeting efficiency, PGP capsules have successfully eradicated subcutaneous tumors in 10 d following a single 5 min NIR irradiation without distal damage. Besides, the photochemothermal therapy of PGP capsules eradicates tumor cells not only in the light-treating area but also widely light-omitted tumor cells, overcoming the tumor recurrence due to efficient cell killing efficacy. These results demonstrate that the PGP capsule is a potential new drug delivery platform for local-targeting, on-demand, photoresponsive, combined chemotherapy/hyperthermia for tumor treatment and other biomedical applications.