• 文献标题:   Ionic liquid modified N-doped graphene as a potential platform for the electrochemical discrimination of DNA sequences
  • 文献类型:   Article
  • 作  者:   SUKUMARAN P, VINEESH TV, RAJAPPA S, LI CZ, ALWARAPPAN S
  • 作者关键词:   ndoped graphene, ionic liquid, label free platform, dna mutation
  • 出版物名称:   SENSORS ACTUATORS BCHEMICAL
  • ISSN:   0925-4005
  • 通讯作者地址:   CSIR
  • 被引频次:   5
  • DOI:   10.1016/j.snb.2017.03.078
  • 出版年:   2017

▎ 摘  要

Inventive designs for DNA-based electrochemical sensing are emerging tremendously in recent years. Herein, we report a label free ionic liquid (1-butyl-3-methylimidazolinium tetrafluoroborate) modified nitrogen doped graphene electrode as a potential platform for the electrochemical discrimination of complementary and non-complementary DNA sequences. The proposed platform holds a great promise for the rapid and selective hand-held detection of DNA sequences with a sensitivity and detection limit of 0.202 mu A/nM/mm(2) and 8.12 nM respectively, without any expensive labeling and cross-hybridization artifacts. (C) 2017 Elsevier B.V. All rights reserved.