▎ 摘　　要

Selective drug release becomes an indispensable criterion for anticancer drug delivery to minimize its hazardous side effects. Here utilizing poly(N-isopropyl acryl amide) anchored graphene oxide (GPNM) having pi-electron rich graphitic basal plane, is employed for carrying drug molecule through non-covalent interactions due to its sufficient stability in cell medium and good dispersibility under physiological condition. The intrinsic fluorescence property of the anticancer drug, berberine becomes quenched on loading with GPNM and after it's selective release to nucleic acids the quenched fluorescence of loaded berberine turns on. But other biomolecules like protein (HSA), sugar etc. are unable to release the drug from the GPNM surface and ds-DNA is more effective than RNA for its release. The intercalative interaction of berberine into the base pairs of nucleic acids has been attributed to the cause of specificity. UV-vis and circular dichroism spectroscopy support the above intercalative mechanism of specific drug delivery.