• 文献标题:   A wearable graphene transistor-based biosensor for monitoring IL-6 biomarker
  • 文献类型:   Article
  • 作  者:   LALIBERTE KE, SCOTT P, KHAN NI, MAHMUD MS, SONG ED
  • 作者关键词:   graphene, fieldeffect transistor, printable, wearable, biosensor, aptamer, interleukin6
  • 出版物名称:   MICROELECTRONIC ENGINEERING
  • ISSN:   0167-9317 EI 1873-5568
  • 通讯作者地址:  
  • 被引频次:   3
  • DOI:   10.1016/j.mee.2022.111835
  • 出版年:   2022

▎ 摘  要

Graphene-based field-effect transistor (GFET) is becoming an increasingly popular biosensing platform for monitoring health conditions through biomarker detection. Moreover, the graphene's 2-dimensional geometry makes it ideal for implementing flexible or wearable electronic devices. If implemented as a wearable biosensor, such technology can non-invasively monitor relevant biomarkers continuously in real-time and alert the user of possible health concerns. As a proof of feasibility, this paper presents a wearable GFET device fabricated on a flexible film that is capable of detecting interleukin-6 (IL-6) protein, a key biomarker implicated in immune responses, in the concentration range of 10 pM to 100 nM. The surface of graphene is modified with targetbinding aptamers to ensure analyte selectivity. Our results show that the biosensor measurements were stable with minimum changes when the GFET was bent with a radius of curvature between 1.5 cm and 4.25 cm suggesting robustness of the flexible GFET device. We have also demonstrated continuous real-time monitoring of IL6 with high sensitivity within the concentration range of 10 pM and 1 nM. Furthermore, a minimum footprint, battery-powered circuit board is also developed that controls the GFET and records the sensor responses in realtime demonstrating the feasibility of becoming a fully standalone and wearable biosensor. The results from this work suggest that the thin film GFET-based biosensor has the potential to be used as a wearable continuous health monitoring device.