▎ 摘　　要

Cobalt phosphate (Co-3(PO4)(2)) has been recognized as a biomimetic superoxide anion (O-2(center dot-)) sensing material, but there is a great challenge to achieve high sensitivity due to its relatively poor conductivity. Here, a unique nanostructure is synthesized by using iodine nanospacer-impregnated reduced graphene oxide (I-rGO) layers to nest Co-3(PO4)(2). The role of iodine greatly enhances the density of nanoscale Co-3(PO4)(2) catalytic centers by separating reduced rGO layers while accelerating the interfacial electron transfer and followed transport through the directionally arranged conductive grapheme layers. The Co-3(PO4)(2)/I-rGO sensor delivers a very good selectivity with a higher sensitivity, shorter response time, and wider linear range than that of Co-3(PO4)(2)/rGO without the iodine nanospacers toward O-2(center dot-) detection, and also the reported Co-3(PO4)(2) nanorods work. Furthermore, the sensor was used to detect O-2(center dot-) generated by prostate cancer cells. This study holds promise for a high value nanoscale biomimetic sensor in practical clinical and bioresearch applications and also demonstrates a rational merit-hybrid nanocomposite design by offering critical contributions from individual components into the biomimetic sensing platform.