▎ 摘　　要

Two-dimensional (2D) nano-materials have provided attraction for many researchers in the innovation of viable routes for large scale synthesis, doping and integration of monolayers and the development of unique materials with excellent properties. Graphene-based 2D nano-materials are promising agents for several biosensor and bioelectronics applications due to their intriguing properties. In this review, a detailed discussion on preparation, synthesis, properties, and characterization of graphene and graphene-based 2D nanomaterials focusing on bioelectronics and biosensors has been carried out and the findings have been provided. Discussions relating to the current review might provide motivation for the future researchers to perform more studies on graphene-based 2D nanomaterials and explore more applications in such a way that it can be used as cost effective alternative for the conventional materials. Further this review provides the crit- ical over look on this topic, highlighting the major unexplored areas which require future investigation.(c) 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).