• 文献标题:   Fabrication of redox and pH dual-responsive magnetic graphene oxide microcapsules via sonochemical method
  • 文献类型:   Article
  • 作  者:   DONG LL, SHI C, GUO LL, YANG T, SUN YX, CUI XJ
  • 作者关键词:   sonochemical, graphene oxide, redoxresponsive, phresponsive, magnetic property, microcapsule
  • 出版物名称:   ULTRASONICS SONOCHEMISTRY
  • ISSN:   1350-4177 EI 1873-2828
  • 通讯作者地址:   Jilin Univ
  • 被引频次:   11
  • DOI:   10.1016/j.ultsonch.2016.12.027
  • 出版年:   2017

▎ 摘  要

In this study, the biocompatible redox and pH dual-responsive magnetic graphene oxide microcapsules (MGOMCs) were prepared by a simple sonochemical method. The disulfide bonds cross-linked the wall of MGOMCs were formed from the hydrosulfuryl on the surface of thiolated graphene oxide, which was synthesized by functionalizing graphene oxide with cysteine, showed an excellent redox-responsive property to control drugs release. Moreover, oleic acid modified Fe3O4 nanoparticles were encapsulated into the microcapsules successfully with the hydrophobic drugs dispersed in the hydroxy silicone oil. The MGOMCs possess distinguished magnetic property and pH-responsive ability. Besides, the microcapsules could be engulfed by Hela cells successfully due to the appropriate size and flexible shell. The MGOMCs could be a good carrier for hydrophobic drugs, especially the anticancer drugs. (C) 2016 Elsevier B.V. All rights reserved.