▎ 摘　　要

Ahighly sensitive and stable TiO2/graphene/chitosan (TiO2/GRP/CHIT) modified glassy carbon electrodewas developed. The sensor exhibits excellent electrocatalytic activity with fast response and convenient determination of an anti-HIV drug Topotecan (TPT). Moreover, from the response characteristics of cyclic voltammetry(CV) and square wave voltammetry (SWV), it was observed that TPT could be effectively accumulated at TiO2/GRP/CHIT/GCE and resulted in a sensitive anodic peak current in Britton-Robinson buffer (pH 5.6). Under the optimized experimental conditions, electro-oxidation of TPT demonstrates linearity within a dynamic concentration of 100 to 1200 ng/mL, with a detection limit of 122.07 ng/mL (LOD) and a quantification limit of 369.9 ng/mL (LOQ). On the basis of the electrochemical measurements, electrode dynamics parameters have been evaluated and the sensor has been successfully employed for determination of TPT in pharmaceutical formulation. (C) 2014 The Electrochemical Society. All rights reserved.