▎ 摘　　要

In this research, we have developed an electrochemical buprenorphine (BN) sensor based on reduced graphene oxide (r-GO) as an electrode modifier on the screen printed carbon electrode (SPCE) surface. BN oxidation pathway was proposed using voltammetric studies and with the aid of Density Functional Theory (DFT). The effects of various parameters including pH, modifier amount, accumulation time, and accumulation potential on the oxidation peak current of BN were optimized. Under the optimized conditions, the linear response range and the limit of detection were obtained as 0.50100 mM and 0.16 mu M (S/N=3) using differential pulse voltammetry (DPV), respectively. The selectivity of the modified electrode in the presence of potential interferences was also studied, and finally the electrode was successfully employed for the determination of BN in spiked urine samples.