▎ 摘　　要

This study theoretically demonstrated an insight for designing a novel tunable plasmonic biosensor, which was created by simply stacking a twisted bilayer graphene (TBG) superlattice onto a plasmonic gold thin film. To achieve ultrasensitive biosensing, the plasmonic biosensor was modulated by Goos-Hanchen (GH) shift. Interestingly, our proposed biosensor exhibited tunable biosensing ability, largely depending on the twisted angle. When the relative twisted angle was optimized to be 55.3 degrees, such a configuration: 44 nm Au film/1-TBG superlattice could produce an ultralow reflectivity of 2.2038 x 10(-9) and ultra-large GH shift of 4.4785 x 10(4) mu m. For a small refractive index (RI) increment of 0.0012 RIU (refractive index unit) in sensing interface, the optimal configuration could offer an ultra-high GH shift detection sensitivity of 3.9570 x 10(7) mu m/RIU. More importantly, the optimal plasmonic configuration demonstrated a theoretical possibility of quantitatively monitoring severe acute respiratory syndrome coronavirus (SARS-CoV-2) and human hemoglobin. Considering an extremely small RI change as little as 3 x 10(-7) RIU, a good linear response between detection concentration of SARS-CoV-2 and changes in differential GH shift was studied. For SARS-CoV-2, a linear detection interval was obtained from 0 to 2 nM. For human hemoglobin, a linear detection range was achieved from 0 to 0.002 g/L. Our work will be important to develop novel TBG-enhanced biosensors for quantitatively detecting microorganisms and biomolecules in biomedical application.