• 文献标题:   A novel and highly sensitive electrochemical sensor based on a high-quality modified graphene electrode for the determination of hydrochlorothiazide in pharmaceutical formulations and human plasma
  • 文献类型:   Article
  • 作  者:   ER E, CELIKKAN H, AKSU ML, ERK N
  • 作者关键词:  
  • 出版物名称:   ANALYTICAL METHODS
  • ISSN:   1759-9660 EI 1759-9679
  • 通讯作者地址:   Ankara Univ
  • 被引频次:   3
  • DOI:   10.1039/c5ay01980j
  • 出版年:   2015

▎ 摘  要

This study is concerned with the development of a practical, efficient and highly sensitive electrochemical sensor for the determination of hydrochlorothiazide (HCT) in pharmaceutical dosage forms or clinical samples using a high-quality modified graphene electrode (H-GRE) which has recently emerged as a very promising material for sensor applications. High-quality graphene (H-GR) was synthesized efficiently by a single-step reduction method from graphene oxide (GO). It was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and transmission electron spectroscopy (TEM). The electrochemical behavior of HCT was investigated using adsorptive stripping differential pulse voltammetry on the H-GRE. The H-GRE showed excellent electrochemical activity for the oxidation of HCT. Under the optimized experimental conditions, the linear response range of HCT was found to be 0.1-48.0 mu M with a detection limit (based on S/N-3) of 19 nM. This improved electrode may provide a promising alternative sensor for the determination of HCT in pharmaceutical formulations and clinical samples.