▎ 摘　　要

The utilization of a sustainable and lightweight graphene aerogel (GA), synthesized from crude biomass, as a cell growth promoter and an adsorbent for the efficient removal of histamine (HIS), a food toxicant, from the real food matrix has been explored. Due to the self-supported three-dimensional nanoporous honeycomb-like structure of the graphene framework and the high surface area, the synthesized GA achieved an 80.69 +/- 0.89% removal of HIS from red wine (spiked with HIS) after just 60 min under both acidic (3.0) and neutral (7.4) pH conditions. Furthermore, simple cleaning with 50% ethanol and deionized water, without any change in weight, allowed them to be reused more than 10 times with a still significant HIS removal ability (more than 71.6 +/- 2.57%). In vitro cell culture experiments demonstrated that the synthesized GA had nontoxic effects on the cell viability (up to 80.35%) even at higher concentrations (10 mg mL(-1)), as determined via the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and lactate dehydrogenase assays using human lung bronchial epithelial cells. Interestingly, GA promotes the wound-healing ability on the scratched epithelial cell surfaces via enhancing the cell migrations as also validated by the western blot analysis via expression levels of epithelial beta-catenin and E-cadherin proteins. The distinct structural advantage along with the nontoxicity of the green synthesized GA will not only facilitate the economic feasibility of the synthesized GA for its practical real-life applications in liquid toxin and pollutant removal from the food and environment but also broaden its applicability as a promising biomaterial of choice for biomedical applications.