• 文献标题:   Poly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances
  • 文献类型:   Review
  • 作  者:   GHOSH S, CHATTERJEE K
  • 作者关键词:   graphene, graphene oxide, peg, poly ethylene glycol, nanomaterial, tissue engineering
  • 出版物名称:   INTERNATIONAL JOURNAL OF NANOMEDICINE
  • ISSN:   1178-2013
  • 通讯作者地址:   Indian Inst Sci
  • 被引频次:   0
  • DOI:   10.2147/IJN.S249717
  • 出版年:   2020

▎ 摘  要

Owing to the unique physical, chemical, mechanical and electrical properties, graphene and its derivatives have been extensively researched for diverse biomedical applications including in tissue engineering since the past decade. Tunable chemical functionalities of graphene oxide (GO), a graphene derivative, allow easy surface functionalization. Functionalization of GO with poly(ethylene glycol) (PEG) (PEG-GO) has received significant attention as it offers superior solubility, stability, and biocompatibility. Besides being an attractive candidate for drug delivery, PEG-GO can aid in the attachment, proliferation, and differentiation of stem cells, thereby augmenting tissue engineering. PEG-GO has shown excellent antibacterial efficacy, which could be an added advantage to minimize implant-associated infections. This review describes the synthesis techniques, properties, and biological potential of PEG-GO towards mammalian and bacterial cells. Studies wherein these nanomaterials have been explored for engineering various tissues are reviewed along with future opportunities in this field.