• 文献标题:   Graphene quantum dot-decorated mesoporous silica nanoparticles for high aspirin loading capacity and its pH-triggered release
  • 文献类型:   Article
  • 作  者:   HUANG SP, SONG LP, XIAO ZD, HU Y, PENG MW, LI JQ, ZHENG XS, WU B, YUAN C
  • 作者关键词:  
  • 出版物名称:   ANALYTICAL METHODS
  • ISSN:   1759-9660 EI 1759-9679
  • 通讯作者地址:   Huazhong Agr Univ
  • 被引频次:   10
  • DOI:   10.1039/c5ay03176a
  • 出版年:   2016

▎ 摘  要

In this paper, fluorescent graphene quantum dots (GQDs) grafted onto the surface of mesoporous silica nanoparticle (MSN) vehicles were prepared and characterized. The as-prepared graphene quantum dot-decorated mesoporous silica nanoparticles (GQD-MSNs) exhibited excellent luminescence properties in vitro. Interestingly, compared to pure MSNs, the specific surface area and pore volume of GQD-MSNs increased by 59.1% and 48.9%, respectively. These optimized features granted GQD-MSNs a high aspirin loading capacity, which was twice as much as that of pure MSN. Moreover, most of the aspirin encapsulated (95.15%) could be released from the surface of GQD-MSNs under acidic conditions (pH 2.5) within 33 h.