• 文献标题:   Improving the glial differentiation of human Schwann-like adipose-derived stem cells with graphene oxide substrates
  • 文献类型:   Article
  • 作  者:   VERRE AF, FARONI A, ILIUT M, SILVA C, MURYN C, REID AJ, VIJAYARAGHAVAN A
  • 作者关键词:   adipose stem cell, graphene, glial differentiation
  • 出版物名称:   INTERFACE FOCUS
  • ISSN:   2042-8898 EI 2042-8901
  • 通讯作者地址:   Univ Manchester
  • 被引频次:   3
  • DOI:   10.1098/rsfs.2018.0002
  • 出版年:   2018

▎ 摘  要

There is urgent need to improve the clinical outcome of peripheral nerve injury. Many efforts are directed towards the fabrication of bioengineered conduits, which could deliver stem cells to the site of injury to promote and guide peripheral nerve regeneration. The aim of this study is to assess whether graphene and related nanomaterials can be useful in the fabrication of such conduits. A comparison is made between graphene oxide (GO) and reduced GO substrates. Our results show that the graphene substrates are highly biocompatible, and the reduced GO substrates are more effective in increasing the gene expression of the biomolecules involved in the regeneration process compared to the other substrates studied.