• 文献标题:   Graphene-based scaffolds for tissue engineering and photothermal therapy
  • 文献类型:   Article
  • 作  者:   PALMIERI V, DE SPIRITO M, PAPI M
  • 作者关键词:   biopolymer, cancer, oncology, graphene, nanomaterial, nanotechnology, nearinfrared, photothermal therapy, scaffold, targeted therapy, tissue engineering
  • 出版物名称:   NANOMEDICINE
  • ISSN:   1743-5889 EI 1748-6963
  • 通讯作者地址:   Univ Cattolica Sacro Cuore
  • 被引频次:   0
  • DOI:   10.2217/nnm-2020-0050
  • 出版年:   2020

▎ 摘  要

Researchers have been creating 3D replicas of damaged tissues for millions of patients by using innovative biomaterials. While these scaffolds have regenerative properties, it would be beneficial if they could be utilized for local therapies, such as for cancer treatment. This report discusses the main advances in graphene scaffold design for near-infrared (NIR) photothermal therapy (PTT). NIR-PTT is a promising alternative for cancer cell killing, mediated by an increase of temperature due to NIR light-absorbers delivered to the tumor proximity. Graphene is a bidimensional material largely exploited in nanomedicine for its unique properties, such as high growth factor loading, which induces cell differentiation and its capacity to absorb NIR light. Here we cover aspects of future research in multifunctional graphene implants for cancer therapy and tissue regeneration.