▎ 摘　　要

A green approach for decarboxylative C(sp(3))-H activation of proline amino acid was accomplished by coupling with aldehydes and alkynes to afford alpha-alkynylated N-substituted pyrrolidines as value-added synthons using reduced graphene oxide supported copper oxide (RGO@CuO) nanocatalysts. The RGO@CuO nanocomposites were obtained by the impregnation of micrometer-sized malachite spheres, as a renewable and sustainable copper mineral precursor, on the graphene oxide (GO) sheets followed by calcination at 300-450 degrees C for 5 h. The characterization of as synthesized composites revealed the generation of mono dispersed and uniformly embedded copper oxide (CuO) nanoparticles with sizes ranging from 10 to 15 nm on RGO thin sheets via GO as a support as well as indirect template for dissembling and decomposition of micrometer-sized malachite spheres. The RGO@CuO composites were found to be efficient and robust nanocatalysts compared with CuO nanoparticles (NPs) alone. The present method offers several advantages, such as wide substrate scope, and avoids the usage of excess equivalent of substrates with minimal waste generation (E-factor = 0.24) and high reaction mass efficiency (80.7%), and the nanocatalyst was recycled for five times without significant loss in its activity with a negligible leaching of CuO NPs from RGO sheets.