• 文献标题:   Alginate foam gel modified by graphene oxide for wound dressing
  • 文献类型:   Article
  • 作  者:   XIE F, ZOU LY, XU ZK, OU XL, GUO WL, GAO Y, GAO GH
  • 作者关键词:   alginate, wound dressing, graphene oxide, hemostasi, wound healing
  • 出版物名称:   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
  • ISSN:   0141-8130 EI 1879-0003
  • 通讯作者地址:  
  • 被引频次:   4
  • DOI:   10.1016/j.ijbiomac.2022.11.013 EA NOV 2022
  • 出版年:   2022

▎ 摘  要

Recently, hydrogel dressings have been rapidly developed for wound healing. However, it is still a huge chal-lenge to endow hydrogel wound dressings with excellent hemostatic performance. Here, a new wound treatment material, foam gel wound dressing, is reported, which possesses rapid hemostasis and antibacterial properties. The foam gel dressing is composed of chitooligosaccharide modified graphene oxide (CG) nanocomposites and calcium alginate foam substrate. In this system, CG has a strong interaction with platelets, which is helpful for rapid hemostasis. So the wound dressing could stop bleeding quickly within 10 s. Meanwhile, CG also provides excellent antibacterial properties to dressings, which is conducive to wound healing. Full-thickness wound healing experiments showed that compared with blank control and CG-free foam gel dressings, CG-loaded foam gel dressings shows better healing properties, and the wounds covered with them are almost completely healed within 12 days. In addition, histological morphology analysis displays CG-loaded wound dressing could signif-icantly accelerate wound healing by reducing the inflammatory response and promoting vascular remodeling. This unique strategy provides a simple and practical method for the clinical application of the next generation of wound dressings.