• 文献标题:   Graphene-Templated Supported Lipid Bilayer Nanochannels
  • 文献类型:   Article
  • 作  者:   LI W, CHUNG JK, LEE YK, GROVES JT
  • 作者关键词:   supported lipid bilayer, graphene, diffusion barrier, nanochannel
  • 出版物名称:   NANO LETTERS
  • ISSN:   1530-6984 EI 1530-6992
  • 通讯作者地址:   Univ Calif Berkeley
  • 被引频次:   10
  • DOI:   10.1021/acs.nanolett.6b01798
  • 出版年:   2016

▎ 摘  要

The use of patterned substrates to impose geometrical restriction on the lateral mobility of molecules in supported lipid membranes has found widespread utility in studies of cell membranes. Here, we template-pattern supported lipid membranes with nanopatterned graphene. We utilize focused ion beam milling to pattern graphene on its growth substrate, then transfer the patterned graphene to fresh glass substrates for subsequent supported membrane formation. We observe that graphene functions as an excellent lateral diffusion barrier for supported lipid bilayers. Additionally, the observed diffusion dynamics of lipids in nanoscale graphene channels reveal extremely low boundary effects, a common problem with other materials. We suggest this is attributable to the ultimate thinness of graphene.