▎ 摘　　要

This study focused on preparation and electrochemical study of mesoporous silica coated graphene oxide nanosheet electrode for determination of glucose. Graphene oxide nanosheets (GO) were prepared using modified Hummer's method on glassy carbon electrode (GCE) and then were chemically coated with mesoporous silica nanoparticles (SiO2). The morphology and structure of synthesized electrodes were studied by SEM and XRD analyses. The differential pulse voltammetry (DPV) and amperometry techniques were applied for electrochemical studies of glucose sensors. Results of structural characterization showed that the GO was prepared in a crumpled, stacked, expanded nanosheet structure. After coating with SiO2, SiO2 nanoparticles were deposited on the GO nanosheets. DPV investigations revealed that the sensor was stable and sensitive for determination of glucose. The amperometry results exhibited that the linear range, limit of detection and sensitivity of sensor were estimated 0 to 900 mu M, 0.03 mu M and 0.97086 mu A/mu M cm(2), respectively, which indicate the limit of detection and sensitivity were more competitive and superior than previous reports of graphene and SiO2 based glucose sensors in literatures. The selectivity and ability of the prepared sensor were examined for detection of glucose in the real human serum sample which indicates the SiO2/GO/ GCE was greatly reliable in practical glucose detection.