▎ 摘　　要

Cancer cells are more susceptible to H2O2 induced cell death than normal cells. H2O2-activatable and O-2-evolving nanoparticles could be used as photodynamic therapy agents in hypoxic environments. In this report, a photo active Mn(II) complex of boradiazaindacene derivatives (Mn-1) was used as a dioxygen generator under irradiation with LED light in water. Moreover, the in vitro biological evaluation for Mn-1 and its loaded graphene oxide (herein called Mn-1@GO) on HepG-2 cells in normal and hypoxic conditions has been performed. In particular, Mn-1@GO can react with H2O2 resulting active anticancer species, which show high inhibition on both HepG-2 cells and CoCl2-treated HepG-2 cells (hypoxic cancer cells). The mechanism of LED light enhanced anticancer activity for Mn-1@GO on HepG-2 cells was discussed. Our results show that Mn(II) complexes of boradiazaindacene (BODIPY) derivatives loaded GO can be both LED light and H2O2-activated anticancer agents in hypoxic environments. (C) 2016 Elsevier Inc. All rights reserved.