• 文献标题:   A Mn(II) complex of boradiazaindacene (BODIPY) loaded graphene oxide as both LED light and H2O2 enhanced anticancer agent
  • 文献类型:   Article
  • 作  者:   XU XL, SHAO J, CHEN QY, LI CH, KONG MY, FANG F, JI L, BOISON D, HUANG T, GAO J, FENG CJ
  • 作者关键词:   manganese, cancer, h2o2activatable, photodynamic, graphene
  • 出版物名称:   JOURNAL OF INORGANIC BIOCHEMISTRY
  • ISSN:   0162-0134 EI 1873-3344
  • 通讯作者地址:   Jiangsu Univ
  • 被引频次:   8
  • DOI:   10.1016/j.jinorgbio.2016.02.007
  • 出版年:   2016

▎ 摘  要

Cancer cells are more susceptible to H2O2 induced cell death than normal cells. H2O2-activatable and O-2-evolving nanoparticles could be used as photodynamic therapy agents in hypoxic environments. In this report, a photo active Mn(II) complex of boradiazaindacene derivatives (Mn-1) was used as a dioxygen generator under irradiation with LED light in water. Moreover, the in vitro biological evaluation for Mn-1 and its loaded graphene oxide (herein called Mn-1@GO) on HepG-2 cells in normal and hypoxic conditions has been performed. In particular, Mn-1@GO can react with H2O2 resulting active anticancer species, which show high inhibition on both HepG-2 cells and CoCl2-treated HepG-2 cells (hypoxic cancer cells). The mechanism of LED light enhanced anticancer activity for Mn-1@GO on HepG-2 cells was discussed. Our results show that Mn(II) complexes of boradiazaindacene (BODIPY) derivatives loaded GO can be both LED light and H2O2-activated anticancer agents in hypoxic environments. (C) 2016 Elsevier Inc. All rights reserved.