▎ 摘　　要

We present a sensitive, fast and unmodified sensor for the electrochemical detection of paracetamol. The electrochemical behaviours of paracetamol on screen printed graphene electrodes were investigated for the first time by cyclic voltammetry. The results showed that the screen printed graphene electrodes revealed exceptional electrocatalytic activity to paracetamol. The response showed by this sensor was enhanced when it was compared to the bare screen printed electrodes. When Screen Printed Graphene Electrodes were compared to bare SPE, it was shown that the response with graphene was greater than without. This is due to its unique characteristics physical and chemical, pi-pi interactions and a strong adsorptive capability. In this manuscript, the effect of supporting electrolyte, pH and scan rate were also investigated. The oxidation peak current was linearly proportional to the concentration of paracetamol in the range from 0.1 to 50 mu M with a limit of detection of 20nM based on (3-sigma/slope), under the optimum conditions. The proposed method was successfully applied to paracetamol determination in in biological samples such as human oral fluid.